G5168
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G5168
Sigma
(Z)-Guggulsterone
≥89% (HPLC), powder
| Synonym: | (17Z)-Pregna-4,17(20)-diene-3,16-dione, 4,17(20)-trans-Pregnadiene-3,16-dione |
| CAS Number: | 39025-23-5 |
| Linear Formula: | C21H28O2 |
| Molecular Weight: | 312.45 |
| MDL number: | MFCD01310757 |
| PubChem Substance ID: | 24278392 |
Description
| Biochem/physiol Actions | (Z)-Guggulsterone is a natural product that lowers cholesterol due to its function as an antagonist ligand for the bile acid receptor. (Z)-Guggulsterone is a nuclear hormone receptor that regulates the transcription of several genes involved in cholesterol metabolism and plays a role in cholesterol level regulation. (Z)-Guggulsterone is also a selective farnesoid X receptor (FXR) modulator. |
Properties
| assay | ≥89% (HPLC) |
| form | powder |
| total impurities | ≤5.4% E-form |
| color | light yellow |
| solubility | DMSO: 5 mg/mL |
| storage temp. | 2-8°C |
Safety
| Personal Protective Equipment | dust mask type N95 (US), Eyeshields, Gloves |
| Hazard Codes | Xi |
| Risk Statements | 37 |
| Safety Statements | 36 |
| WGK Germany | 3 |
References
| reference | Urizar, N.L., et al., A natural product that lowers cholesterol as an antagonist ligand for the FXR. Science 296, 1703-1706, (2000) |
| Meyer, U., et al., Is antagonism of E/Z-Guggulsterone at the farnesoid X receptor mediated by a noncanonical binding site? A molecular modeling study. J. Med. Chem. 48, 6948-6955, (2005) |
